10-8
Map the interview terrain
- Practise two-science switching
- Use the ESAT module structure to organise revision
- Match ESAT modules to your strongest current subjects
Real Natural Sciences interview questions in the style Cambridge asks. Try answering each one aloud before you reveal the hint.
A 5 kg box is in a lift accelerating upwards at 4 m s^-2. Find the tension in the supporting rope, then explain what changes if a second identical box is attached beneath it by another rope.
Problem-Solving
Hint
Start with a free-body diagram and apply Newton's second law separately to each box.
Two identical beakers sit on a balance. One contains a submerged steel ball suspended by a string from outside the beaker; the other contains a floating plastic ball. Which side is heavier, and why?
Problem-Solving
Hint
Think about which object transfers its weight to the beaker and which transfers only the buoyant reaction force.
An ice cube floats in a glass of water. When it melts, does the water level rise, fall or stay the same?
Problem-Solving
Hint
Use Archimedes' principle and compare the displaced water with the melted ice volume.
Three identical capacitors are connected in series. Derive the equivalent capacitance and explain why it is smaller than the capacitance of any one capacitor.
Problem-Solving
Hint
Use common charge in a series circuit and add the potential differences across each capacitor.
A cube is made of identical resistors on each edge. How would you find the resistance between opposite corners?
Problem-Solving
Hint
Look for symmetry: points at the same potential can be joined or separated without changing the current distribution.
Supervision-style interviews with problem-solving and academic discussion, often with two interviewers.
Cambridge interviews usually happen at your first-choice college. Most applicants have two interviews, with some subjects requiring a third at the pooled college. Cambridge interviews tend to involve two interviewers and may include a written assessment or pre-interview task sent on the day.
Interview Invitation
Late Nov
Arrival to Interview
Early Dec
Technical Question
Mid Dec
Decision
Early Jan
Interview Invitation
Late Nov
Arrival to Interview
Early Dec
Technical Question
Mid Dec
Decision
Early Jan
What information does a rate equation give you, and how could you use experimental data to determine the order of reaction?
midHint
Separate what is inferred from the balanced equation from what must be measured experimentally.
Why is benzene usually drawn with a circle inside a hexagon, and what does that representation fail to show?
midHint
Discuss delocalised electrons, equal bond lengths and the difference between a model and a literal structure.
How can amino acids behave as both acids and bases?
midHint
Identify the functional groups and think about proton donation and acceptance at different pH values.
What problems do fish face by living underwater?
midHint
Consider oxygen availability, osmoregulation, buoyancy, pressure, locomotion and sensory systems.
You wrote about measuring Planck's constant in your personal statement. Talk us through the experimental method and the main sources of uncertainty.
midHint
Explain the apparatus first, then identify what was measured, what was inferred and where systematic error could enter.
You mention a specific scientific experience in your personal statement. What did it change about the way you think about science?
entryHint
Avoid retelling the activity; focus on a concept, method or assumption you now understand differently.
You have read about quantum computing. What physical problems do researchers face, and how are they trying to overcome them?
hardHint
Distinguish the idea of a qubit from the engineering problems of coherence, noise, error correction and scalability.
A rubbery ball is found on Mars. How would you decide whether it is alive?
hardHint
Start by defining operational criteria for life, then propose tests and possible false positives.
Estimate the number of atoms in a Brussels sprout.
midHint
Estimate mass, approximate composition as mostly water and organic material, then convert to molecules or atoms.
What drug might make someone a better marksman, and what scientific and ethical issues would you consider before answering?
hardHint
Separate physiological mechanisms such as tremor, heart rate and attention from safety, consent, fairness and misuse.
A performance-enhancing drug could reduce tremor or anxiety in a high-pressure task. How would you decide whether it should be tested or allowed?
midHint
Separate physiological evidence from medical safety, consent, fairness and possible misuse.
10-8
8-6
6-4
4-2
2-0
Cambridge NatSci interviews test your scientific reasoning across multiple disciplines. You may be given problems spanning physics, biology, and chemistry, often using unfamiliar contexts to see how you apply fundamental principles.
Q1. Why is ice less dense than water, and what would happen to life on Earth if it were denser?
How to approach this: Start with the chemistry: hydrogen bonding in water creates an open hexagonal lattice in ice, making it less dense. Then reason through the biology: if ice sank, lakes and oceans would freeze from the bottom up, eliminating aquatic habitats. Consider the feedback loops on global temperature and whether complex life could have evolved at all.
Q2. Estimate how many molecules you breathe in that were also breathed by Julius Caesar.
How to approach this: This is a Fermi estimation spanning physics and chemistry. Estimate the number of molecules in a single breath (~2.5 x 10^22), the total molecules in the atmosphere (~10^44), and assume Caesar's breaths have fully mixed over 2,000 years. The ratio gives a surprisingly high probability of overlap. Show your working and state assumptions clearly.
Q3. A patient has a genetic mutation that prevents them producing functional haemoglobin. What symptoms would you expect, and how might you treat them?
How to approach this: Start with the biology of haemoglobin: oxygen transport, the role of iron, and the quaternary structure. Predict symptoms from first principles (fatigue, pallor, organ damage from hypoxia). For treatment, reason through options: blood transfusions, gene therapy, and why a bone marrow transplant targets the root cause. Link to real conditions like sickle cell disease or thalassaemia.
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Further Reading
by University of Cambridge
UCAS code BCF0; Natural Sciences, BA (Hons) and MSci; 3 or 4 years full-time; all Colleges.; A-level requirement A*A*A; IB requirement 41-42 with 776 at Higher Level.
by University of Cambridge
Cambridge applicants must take the first ESAT sitting, 12-16 October 2026.; Registration opens 20 July 2026 and booking closes 28 September 2026.
by University of Cambridge
Interviews are academic conversations assessing potential, subject understanding, independent thinking and readiness for Cambridge-style learning.; Main interview period for 2027 entry is 7-18 December 2026.
by University of Cambridge
Natural Sciences had 2,644 applications, 672 offers and 576 acceptances in the 2025 cycle.; Official Natural Sciences success rate for the 2025 cycle was 21.8%.
by University of Cambridge
Decisions consider academic record, reference, personal statement, written assessment, contextual data and interview performance.; Applications can be placed in the Winter Pool so other Colleges can consider them.